What is Glutathione

What is Glutathione?

Glutathione is a combination of three amino acids: cysteine, glutamic acid, and glycine. Your liver naturally makes this substance in your body. And it helps with many bodily functions like making and repairing tissue, creating needed proteins and chemicals, and supporting proper immune system function.

What is Glutathione Synthetase Deficiency?


In general, Glutathione synthetase deficiency is an inherited metabolic disorder that causes your body to not be able to produce enough glutathione. As a result, patients may have symptoms that are mild, moderate, or severe. This disorder is caused by genetic changes like mutations in the GSS gene. Further, it is passed along in an autosomal recessive manner. Usually, the first sign that may cause a doctor to think you have this disorder is metabolic acidosis. In fact, mild cases of Glutathione synthetase deficiency show signs and symptoms like:

  • Hemolytic anemia: Breaking down red blood cells to quickly and not replacing them fast enough.
    – Shortness of breath.
    – Nausea.
    – Lightheadedness.
    – Fatigue.
  • Splenomegaly: abnormally large spleen.

Glutathione synthetase deficiency

On the other hand, signs and symptoms of moderate Glutathione Synthetase Deficiency includes:

  • Hemolytic anemia.
  • Buildup of 5-oxoproline in the urine (5-oxoprolinuria).
  • Metabolic acidosis: too much acid in your body.
    – Nausea.
    – Vomiting.
    – Fatigue.

Finally, severe cases of this disorder have all signs and symptoms of mild and moderate cases plus:

  • Neurological issues: seizures, trouble with coordinating movements (ataxia), and intellectual disabilities.
  • In children: developmental delay (sitting and walking), speech delay (learning to talk), spasticity (stiff muscles), and repeated bacterial infections.
  • In adults: retinal dystrophy (vision problems).

Usually, moderate and severe cases show signs and symptoms during infancy. However, mild cases go unnoticed until later in life.

What are the benefits of Glutathione?

What are the benefits of Glutathione

Primarily, Glutathione helps with nerve damage caused by cancer drug cisplatin. However, other benefits include helping treat conditions, such as:

  • Lyme disease.
  • Alzheimer’s disease.
  • Alcoholism.
  • Osteoarthritis.
  • Asthma.
  • Cataracts.
  • Clogged arteries (atherosclerosis).
  • Colitis.
  • Diabetes.
  • High cholesterol.
  • Chronic fatigue syndrome.
  • Hepatitis.
  • Liver disease.
  • Parkinson’s disease.
  • Heart disease.
  • Glaucoma.

What are the side effects of Glutathione?

What are the side effects of Glutathione

There is not a lot of information regarding side effects of Glutathione used by mouth, shot/IV, skin, or inhalation. However, some people experience allergic reactions like rashes, cramping, and bloating.

Who should take caution with Glutathione?

In general, it is safe for people to take Glutathione. However, pregnant and breast-feeding women as well as people with asthma should take caution when using this substance. There is not enough evidence to say if it is safe for these groups of people.

Are there any interactions between Glutathione and other drugs?

Are there any interactions between Glutathione and other drugs

Glutathione has no known interactions.

How much Glutathione should you take a day?

How much Glutathione should you take a day

Glutathione is mainly used as an IV or shot to treat nerve damage caused by cancer drug cisplatin. The recommended dosage is as follows:

  • 1.5 to 3 grams/m2 given 15-20 minutes right before chemotherapy.
  • 1.5 grams/m2 given over 15 minutes before chemotherapy and 600mg on days 2 through 5.
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